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    p62/SQSTM1
    时间:2019-02-15 21:21  浏览次数:825次
    Gene Name ACCN Restriction Sites TAG Selection Species Mutation/Deletion Vector Description Catalog Price
    p62/SQSTM1
    NM_001290769.1
    13 ( NotI, XhoI )
    None
    None
    Mouse
    None
    PCMV
    2-1-010



    This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.