p62/SQSTM1
时间:2019-02-15 23:12 浏览次数:970次
p62/SQSTM1
NM_001142298.1
GFP
None
Human
NES (2269...2272=gaag (atcg) )
PCMV
2-1-009-3

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.